Article
BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains.
Oncogene - 3 Oct 2002
Magnard Clémence, Bachelier Richard, Vincent Anne, Jaquinod Michel, Kieffer Sylvie, Lenoir Gilbert M, Venezia Nicole Dalla
Abstract excerpt
Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. BRCA1 is a 220-kDa protein that contains a tandem of two BRCA1 C-Terminal (BRCT) domains. Among missense and nonsense BRCA1 mutations responsible for family breast cancer, some are located into the BRCT tandem of BRCA1 coding sequence. In an attempt to understand how BRCT is critical for BRCA1 function, we...
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