Article
The effect of ACACB cis-variants on gene expression and metabolic traits.
PloS one - 1 Jan 2011
Ma Lijun, Mondal Ashis K, Murea Mariana, Sharma Neeraj K, Tönjes Anke, Langberg Kurt A, Das Swapan K, Franks Paul W, Kovacs Peter, Antinozzi Peter A, Stumvoll Michael, Parks John S, Elbein Steven C, Freedman Barry I
Abstract excerpt
BACKGROUND: Acetyl Coenzyme A carboxylase β (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Systematic human studies have not been performed to evaluate whether ACACB variants regulate gene expression and insulin sensitivity in skeletal muscle and adipose tissues. We sought to determine whether ACACB...
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