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Article

BRCA1 and acetyl-CoA carboxylase: the metabolic syndrome of breast cancer.

Molecular carcinogenesis - 1 Feb 2008

Brunet Joan, Vazquez-Martin Alejandro, Colomer Ramon, Graña-Suarez Begoña, Martin-Castillo Begoña, Menendez Javier A

Abstract excerpt

Breast cancer-associated mutations affecting the highly-conserved C-terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl coenzyme A carboxylase alpha (ACCA), the rate-limiting enzyme catalyzing de novo fatty acid biogenesis. Specifically, BRCA1 interacts solely with the phosphorylated (inactive) form of ACCA...

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Share to Acetyl-CoA Carboxylase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17620310
DOI: 10.1002/mc.20364

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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