Article

Acetyl-CoA carboxylase 1-dependent lipogenesis drives breast cancer progression

2023-07-22

Abstract excerpt

Dysregulation of cellular energetics, including lipid synthesis mediated through de novo lipogenesis, is a feature of many cancers. Here we report that acetyl-coenzyme A carboxylase (ACC) 1, the rate-limiting enzyme of de novo lipogenesis, is a key regulator of breast cancer progression and cancer cell phenotype. Mammary epithelial-specific deletion of ACC1 impaired tumour progression and decreased cancer cell pro...

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Literature Corpus work: 6b35a771-8bcd-5126-9294-36279a1c9c8a
DOI: 10.1101/2023.07.20.549828

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