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Article

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.

Molecular biology of the cell - 1 Nov 2004

Pebernard Stephanie, McDonald W Hayes, Pavlova Yelena, Yates John R, Boddy Michael N

Abstract excerpt

The structural maintenance of chromosomes (SMC) family of proteins play key roles in the organization, packaging, and repair of chromosomes. Cohesin (Smc1+3) holds replicated sister chromatids together until mitosis, condensin (Smc2+4) acts in chromosome condensation, and Smc5+6 performs currently enigmatic roles in DNA repair and chromatin structure. The SMC heterodimers must associate with non-SMC subunits to...

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Identifiers

PMID: 15331764
DOI: 10.1091/mbc.e04-05-0436
PMCID: PMC524734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.PMID 15331764Read ↗

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.Semantic proximity Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

Characterization of the NSE6 subunit of the <i>Physcomitrium patens</i> PpSMC5/6 complexSemantic proximity Read ↗

Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.Semantic proximity Read ↗

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.Semantic proximity Read ↗

Structure Basis for Shaping the Nse4 Protein by the Nse1 and Nse3 Dimer within the Smc5/6 Complex.Semantic proximity Read ↗

Allelic Analysis of smc-6 Reveals Domain-Specific Roles in DNA Repair in Caenorhabditis elegans.Semantic proximity Read ↗

Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression.Semantic proximity Read ↗

Separation-of-Function Alleles of smc-5 Reveal Domain-Specific Defects and a Conserved Residue Critical for Genome Maintenance.Semantic proximity Read ↗

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