Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.

doi:10.1074/jbc.M308828200

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Article

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.

The Journal of biological chemistry - 14 Nov 2003

McDonald W Hayes, Pavlova Yelena, Yates John R, Boddy Michael N

Abstract excerpt

The structural maintenance of chromosomes (SMC) family of proteins play essential roles in genomic stability. SMC heterodimers are required for sister-chromatid cohesion (Cohesin: Smc1 & Smc3), chromatin condensation (Condensin: Smc2 & Smc4), and DNA repair (Smc5 & Smc6). The SMC heterodimers do not function alone and must associate with essential non-SMC subunits. To gain further insight into the essential and...

Topics

Alleles
Amino Acid Sequence
Cell Cycle Proteins
Cell Nucleus
Chromatin
Chromatography, Gel
DNA Damage
DNA Repair
DNA-Binding Proteins
Dimerization
Dose-Response Relationship, Radiation
Gene Deletion
Mass Spectrometry
Molecular Sequence Data

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Mutation

Nuclear Proteins

Peptides

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Identifiers

PMID: 12966087
DOI: 10.1074/jbc.M308828200

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