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Article

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.

The Journal of biological chemistry - 14 Nov 2003

McDonald W Hayes, Pavlova Yelena, Yates John R, Boddy Michael N

Abstract excerpt

The structural maintenance of chromosomes (SMC) family of proteins play essential roles in genomic stability. SMC heterodimers are required for sister-chromatid cohesion (Cohesin: Smc1 & Smc3), chromatin condensation (Condensin: Smc2 & Smc4), and DNA repair (Smc5 & Smc6). The SMC heterodimers do not function alone and must associate with essential non-SMC subunits. To gain further insight into the essential and...

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PMID: 12966087
DOI: 10.1074/jbc.M308828200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.PMID 12966087Read ↗

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.Semantic proximity Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.Semantic proximity Read ↗

Structure Basis for Shaping the Nse4 Protein by the Nse1 and Nse3 Dimer within the Smc5/6 Complex.Semantic proximity Read ↗

Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression.Semantic proximity Read ↗

Molecular Insights into the Architecture of the Human SMC5/6 Complex.Semantic proximity Read ↗

Separation-of-Function Alleles of smc-5 Reveal Domain-Specific Defects and a Conserved Residue Critical for Genome Maintenance.Semantic proximity Read ↗

Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.Semantic proximity Read ↗

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