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Article

Structure Basis for Shaping the Nse4 Protein by the Nse1 and Nse3 Dimer within the Smc5/6 Complex.

Journal of molecular biology - 30 Apr 2021

Jo Aera, Li Shibai, Shin Jin Woo, Zhao Xiaolan, Cho Yunje

Abstract excerpt

The Smc5/6 complex facilitates chromosome replication and DNA break repair. Within this complex, a subcomplex composed of Nse1, Nse3 and Nse4 is thought to play multiple roles through DNA binding and regulating ATP-dependent activities of the complex. However, how the Nse1-Nse3-Nse4 subcomplex carries out these multiple functions remain unclear. To address this question, we determine the crystal structure of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33676928
DOI: 10.1016/j.jmb.2021.166910
PMCID: PMC8173833

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