Allelic Analysis of smc-6 Reveals Domain-Specific Roles in DNA Repair in Caenorhabditis elegans.

doi:10.3390/ijms27114843

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Article

Allelic Analysis of smc-6 Reveals Domain-Specific Roles in DNA Repair in Caenorhabditis elegans.

International journal of molecular sciences - 27 May 2026

Liang Yiqiang, Zhang Yingling, Xie Junkai, Xiao Qice, Liao Guiyan, Lu Jie

Abstract excerpt

The Structural Maintenance of Chromosomes complex 5/6 (SMC-5/6) safeguards genome stability by coordinating DNA replication, repair, and chromosome organization. Although prior studies have advanced understanding of SMC-6, a domain-resolved view of its functions in vivo, particularly in multicellular organisms, remains incomplete. Because the non-SMC subunit NSE-1 localizes at the SMC-5/6 head interface and...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
DNA Repair
Alleles
Polymorphism, Single Nucleotide
Mutation
Protein Domains

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Identifiers

PMID: 42278373
DOI: 10.3390/ijms27114843
PMCID: PMC13256955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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