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Article

Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.

Molecular and cellular biology - 1 Jan 2005

Andrews Emily A, Palecek Jan, Sergeant John, Taylor Elaine, Lehmann Alan R, Watts Felicity Z

Abstract excerpt

The Schizosaccharomyces pombe SMC proteins Rad18 (Smc6) and Spr18 (Smc5) exist in a high-M(r) complex which also contains the non-SMC proteins Nse1, Nse2, Nse3, and Rad62. The Smc5-6 complex, which is essential for viability, is required for several aspects of DNA metabolism, including recombinational repair and maintenance of the DNA damage checkpoint. We have characterized Nse2 and show here that it is a SUMO...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15601841
DOI: 10.1128/MCB.25.1.185-196.2005
PMCID: PMC538766

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.PMID 15601841Read ↗

Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.Semantic proximity Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.Semantic proximity Read ↗

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.Semantic proximity Read ↗

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Semantic proximity Read ↗

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

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A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.Semantic proximity Read ↗

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