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Article

Separation-of-Function Alleles of smc-5 Reveal Domain-Specific Defects and a Conserved Residue Critical for Genome Maintenance.

Biomolecules - 23 May 2025

Yuan Haiyan, Odiba Arome Solomon, Liao Guiyan, Zhou Ziteng, Fang Wenxia, Jin Cheng, Li Shaojun, Liu Xihui, Wang Bin

Abstract excerpt

The SMC-5/6 complex safeguards genome stability through the coordinated action of its core SMC proteins and associated NSE subunits. NSE-1 is a key component of the complex and is essential for DNA repair, yet it remains poorly characterized in Caenorhabditis elegans. To further elucidate the functional mechanisms of NSE-1, we performed an EMS-based forward genetic screen in an nse-1::gfp(wsh1) reporter strain to...

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PMID: 40563397
DOI: 10.3390/biom15060755
PMCID: PMC12191127

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