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Article

Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression.

Cellular and molecular life sciences : CMLS - 7 Jun 2024

Lorite Neus P, Apostolova Sonia, Guasch-Vallés Marta, Pryer Aaron, Unzueta Fernando, Freire Raimundo, Solé-Soler Roger, Pedraza Neus, Dolcet Xavier, Garí Eloi, Agell Neus, Taylor Elaine M, Colomina Neus, Torres-Rosell Jordi

Abstract excerpt

The Smc5/6 complex is a highly conserved molecular machine involved in the maintenance of genome integrity. While its functions largely depend on restraining the fork remodeling activity of Mph1 in yeast, the presence of an analogous Smc5/6-FANCM regulation in humans remains unknown. We generated human cell lines harboring mutations in the NSE1 subunit of the Smc5/6 complex. Point mutations or truncations in the...

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Identifiers

PMID: 38847937
DOI: 10.1007/s00018-024-05275-3
PMCID: PMC11335289

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