Article
Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.
Molecular and cellular biology - 1 Nov 2004
Morikawa Hirofumi, Morishita Takashi, Kawane Shiho, Iwasaki Hiroshi, Carr Antony M, Shinagawa Hideo
Abstract excerpt
Smc5 and Smc6 proteins form a heterodimeric SMC (structural maintenance of chromosome) protein complex like SMC1-SMC3 cohesin and SMC2-SMC4 condensin, and they associate with non-SMC proteins Nse1 and Nse2 stably and Rad60 transiently. This multiprotein complex plays an essential role in maintaining chromosome integrity and repairing DNA double strand breaks (DSBs). This study characterizes a Schizosaccharomyces...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.