Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.

doi:10.1074/jbc.M201523200

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Article

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.

The Journal of biological chemistry - 14 Jun 2002

Fujioka Yoko, Kimata Yukio, Nomaguchi Koji, Watanabe Kenji, Kohno Kenji

Abstract excerpt

Structural maintenance of chromosomes (SMC) proteins play central roles in chromosome organization and dynamics. They have been classified into six subtypes, termed SMC1 to SMC6, and function as heterodimer components of large protein complexes that also include several non-SMC proteins. The SMC2-SMC4 and SMC1-SMC3 complexes are also known as condensin and cohesin, respectively, but the recently identified SMC5...

Topics

Amino Acid Sequence
Blotting, Western
Cell Cycle Proteins
Cell Division
Cell Nucleus
Chromatography, Gel
Chromosomes
DNA Damage
DNA Repair
DNA-Binding Proteins
Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

Phenotype

Plasmids

Precipitin Tests

Recombination, Genetic

Source

Open in PubMed

Identifiers

PMID: 11927594
DOI: 10.1074/jbc.M201523200

Genes

SMC6
SMC5
SMC2
SMC3
SMC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.PMID 11927594Read ↗

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.Semantic proximity Read ↗

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Semantic proximity Read ↗

Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.Semantic proximity Read ↗

Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.Semantic proximity Read ↗

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Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.Semantic proximity Read ↗

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.Semantic proximity Read ↗

Allelic Analysis of smc-6 Reveals Domain-Specific Roles in DNA Repair in Caenorhabditis elegans.Semantic proximity Read ↗

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.Semantic proximity Read ↗

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