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Article

Coordination of DNA damage responses via the Smc5/Smc6 complex.

Molecular and cellular biology - 1 Jan 2004

Harvey Susan H, Sheedy Daniel M, Cuddihy Andrew R, O'Connell Matthew J

Abstract excerpt

The detection of DNA damage activates DNA repair pathways and checkpoints to allow time for repair. Ultimately, these responses must be coordinated to ensure that cell cycle progression is halted until repair is completed. Several multiprotein complexes containing members of the structural maintenance of chromosomes family of proteins have been described, including the condensin and cohesin complexes, that are...

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Identifiers

PMID: 14701739
DOI: 10.1128/MCB.24.2.662-674.2004
PMCID: PMC343814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordination of DNA damage responses via the Smc5/Smc6 complex.PMID 14701739Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.Semantic proximity Read ↗

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Semantic proximity Read ↗

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.Semantic proximity Read ↗

During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.Semantic proximity Read ↗

Smc5/6 is required for repair at collapsed replication forks.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster.Semantic proximity Read ↗

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Specialized interfaces of Smc5/6 control hinge stability and DNA association.Semantic proximity Read ↗

Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.Semantic proximity Read ↗

Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression.Semantic proximity Read ↗

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