Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I

22 Jul 2009

Abstract excerpt

Proteolytic activity of separase is required for chiasma resolution during meiosis I in mouse oocytes. Rec8, the meiosis-specific alpha-kleisin subunit of cohesin, is a key target of separase in yeast. Is the equivalent protein also a target in mammals? We show here that separase cleaves mouse Rec8 at three positions in vitro but only when the latter is hyper-phosphorylated. Expression of a Rec8 variant (Rec8-N)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics and Chromatin Dynamics
Share to Microtubule and mitosis dynamics
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19625504
DOI: 10.1242/jcs.035287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis IPMID 19625504Read ↗

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.Semantic proximity Read ↗

Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin.Semantic proximity Read ↗

Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.Semantic proximity Read ↗

Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast.Semantic proximity Read ↗

Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure.Semantic proximity Read ↗

Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L.Semantic proximity Read ↗

Cohesin Rec8 is required for reductional chromosome segregation at meiosis.Semantic proximity Read ↗

MicroRNA‐202 safeguards meiotic progression by preventing premature SEPARASE‐mediated REC8 cleavageSemantic proximity Read ↗

Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes1Semantic proximity Read ↗

Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans.Semantic proximity Read ↗

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.Semantic proximity Read ↗

Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.