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Article

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.

Developmental cell - 16 Mar 2010

Katis Vittorio L, Lipp Jesse J, Imre Richard, Bogdanova Aliona, Okaz Elwy, Habermann Bianca, Mechtler Karl, Nasmyth Kim, Zachariae Wolfgang

Abstract excerpt

During meiosis, two rounds of chromosome segregation after a single round of DNA replication produce haploid gametes from diploid precursors. At meiosis I, maternal and paternal kinetochores are pulled toward opposite poles, and chiasmata holding bivalent chromosomes together are resolved by cleavage of cohesin's alpha-kleisin subunit (Rec8) along chromosome arms. This creates dyad chromosomes containing a pair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20230747
DOI: 10.1016/j.devcel.2010.01.014
PMCID: PMC2994640

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Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.PMID 20230747Read ↗

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