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Article

Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin.

Nature - 10 Jan 2013

McAleenan Alexandra, Clemente-Blanco Andres, Cordon-Preciado Violeta, Sen Nicholas, Esteras Miguel, Jarmuz Adam, Aragón Luis

Abstract excerpt

DNA double-strand break repair is critical for cell viability and involves highly coordinated pathways to restore DNA integrity at the lesion. An early event during homology-dependent repair is resection of the break to generate progressively longer 3' single-strand tails that are used to identify suitable templates for repair. Sister chromatids provide near-perfect sequence homology and are therefore the...

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Identifiers

PMID: 23178808
DOI: 10.1038/nature11630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin.PMID 23178808Read ↗

Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.Semantic proximity Read ↗

Cohesin regulates homology search during recombinational DNA repair.Semantic proximity Read ↗

Postreplicative formation of cohesion is required for repair and induced by a single DNA break.Semantic proximity Read ↗

DNA helicases Sgs1 and BLM promote DNA double-strand break resection.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

Structure and stability of cohesin's Smc1-kleisin interaction.Semantic proximity Read ↗

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids.Semantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

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Rad9/53BP1 promotes crossover recombination DNA repair by limiting the Sgs1 and Mph1 helicasesSemantic proximity Read ↗

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