Article
The Saccharomyces cerevisiae PDS1 and RAD9 checkpoint genes control different DNA double-strand break repair pathways.
DNA repair - 2 Jan 2005
DeMase David, Zeng Li, Cera Cinzia, Fasullo Michael
Abstract excerpt
In response to DNA damage, the Saccharomyces cerevisiae securin Pds1 blocks anaphase promotion by inhibiting ESP1-dependent degradation of cohesins. PDS1 is positioned downstream of the MEC1- and RAD9-mediated DNA damage-induced signal transduction pathways. Because cohesins participate in postreplicative repair and the pds1 mutant is radiation sensitive, we identified DNA repair pathways that are PDS1-dependent....
Topics
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Crosses, Genetic
- DNA Primers
- DNA Repair
- DNA-Binding Proteins
- Fungal Proteins
- Genotype
- Karyotyping
- Methyl Methanesulfonate
- Mutation