Article
Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening.
Infection and immunity - 1 Sept 2004
Hisert Katherine B, Kirksey Meghan A, Gomez James E, Sousa Alexandra O, Cox Jeffery S, Jacobs William R, Nathan Carl F, McKinney John D
Abstract excerpt
Tuberculosis (TB) is characterized by lifetime persistence of Mycobacterium tuberculosis. Despite the induction of a vigorous host immune response that curtails disease progression in the majority of cases, the organism is not eliminated. Subsequent immunosuppression can lead to reactivation after a prolonged period of clinical latency. Thus, while it is clear that protective immune mechanisms are engaged during...
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