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Article

Aberrant adaptive immune response underlies genetic susceptibility to tuberculosis.

Frontiers in immunology - 1 Jan 2024

Tsareva Anastasiia, Shelyakin Pavel V, Shagina Irina A, Myshkin Mikhail Yu, Merzlyak Ekaterina M, Kriukova Valeriia V, Apt Alexander S, Linge Irina A, Chudakov Dmitriy M, Britanova Olga V

Abstract excerpt

Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analysis of two mouse strains to uncover relevant mechanisms underlying susceptibility and resistance. C57BL/6 mice are relatively TB-resistant, whereas I/St mice are prone...

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Identifiers

PMID: 38799462
DOI: 10.3389/fimmu.2024.1380971
PMCID: PMC11116662

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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