Article

Genome-wide screen identifies host loci that modulate <i>M. tuberculosis</i> fitness in immunodivergent mice

2023-03-06

Abstract excerpt

Genetic differences among mammalian hosts and Mycobacterium tuberculosis ( Mtb ) strains determine diverse tuberculosis (TB) patient outcomes. The advent of recombinant inbred mouse panels and next-generation transposon mutagenesis and sequencing approaches has enabled dissection of complex host- pathogen interactions. To identify host and pathogen genetic determinants of Mtb pathogenesis, we infected members o...

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Literature Corpus work: 2d5727d2-cd59-545b-8fda-70de0671954d
DOI: 10.1101/2023.03.05.528534

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