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Identification of a virulence gene cluster of <i>Mycobacterium tuberculosis</i> by signature‐tagged transposon mutagenesis

1 Oct 1999

Abstract excerpt

Tuberculosis remains the greatest cause of death worldwide due to a single pathogen. In order to identify the genes required for the pathogenicity of Mycobacterium tuberculosis, a functional genomic approach was developed. A library of signature-tagged transposon mutants of this bacterium was constructed and screened for those affected in their multiplication within the lungs of mice. From 1927 mutants tested, 16...

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PMID: 10564470
DOI: 10.1046/j.1365-2958.1999.01593.x

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