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Article

Tuberculosis susceptibility in genetically diverse mice reveals functional diversity of neutrophils.

eLife - 12 Sept 2025

Ravesloot-Chavez Marietta M, Van Dis Erik, Fox Douglas, Anaya-Sanchez Andrea, Espich Scott, Nguyenla Xammy Huu, Rawal Sagar, Samani Helia, Ballinger Mallory, Thomas Henry F, Kotov Dmitri I, Vance Russell E, Nachman Michael W, Stanley Sarah A

Abstract excerpt

Tuberculosis is a heterogeneous disease in humans with individuals exhibiting a wide range of susceptibility. This heterogeneity is not captured by standard laboratory mouse lines. We used a new collection of 19 wild-derived inbred mouse lines collected from diverse geographic sites to identify novel phenotypes during Mycobacterium tuberculosis (Mtb) infection. Wild-derived mice have heterogeneous immune...

Read the complete abstract on PubMed

Topics

Animals
Neutrophils
Mice
Mycobacterium tuberculosis
Tuberculosis
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Genetic Predisposition to Disease

Lung

Mice, Inbred C57BL

Disease Susceptibility

Disease Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 40937719
DOI: 10.7554/eLife.102441
PMCID: PMC12431774

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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