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Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans

8 Mar 2025

Abstract excerpt

While control of Mycobacterium tuberculosis (Mtb) infection is generally understood to require Th1 cells and IFNγ, infection produces a spectrum of immunological and pathological phenotypes in diverse human populations. By characterizing Mtb infection in mouse strains that model the genetic heterogeneity of an outbred population, we identified strains that control Mtb comparably to a standard IFNγ-dependent mouse...

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PMID: 40192640
DOI: 10.1084/jem.20241760

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