Article
A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y.
PLoS pathogens - 1 Apr 2024
Bobba Suhas, Chauhan Kuldeep S, Akter Sadia, Das Shibali, Mittal Ekansh, Mathema Barun, Philips Jennifer A, Khader Shabaana A
Abstract excerpt
Interleukin-1 (IL-1) signaling is essential for controlling virulent Mycobacterium tuberculosis (Mtb) infection since antagonism of this pathway leads to exacerbated pathology and increased susceptibility. In contrast, the triggering of type I interferon (IFN) signaling is associated with the progression of tuberculosis (TB) disease and linked with negative regulation of IL-1 signaling. However, mice lacking IL-1...
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