Article
Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes.
Infection and immunity - 1 Jul 2006
Keller Christine, Hoffmann Reinhard, Lang Roland, Brandau Sven, Hermann Corinna, Ehlers Stefan
Abstract excerpt
Classical twin studies and recent linkage analyses of African populations have revealed a potential involvement of host genetic factors in susceptibility or resistance to Mycobacterium tuberculosis infection. In order to identify the candidate genes involved and test their causal implication, we capitalized on the mouse model of tuberculosis, since inbred mouse strains also differ substantially in their...
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