Article

Rapid lethality of mice lacking the phagocyte oxidase and Caspase1/11 following <i>Mycobacterium tuberculosis</i> infection

2023-02-11

Abstract excerpt

Immune networks that control antimicrobial and inflammatory mechanisms have overlapping regulation and functions to ensure effective host responses. Genetic interaction studies of immune pathways that compare host responses in single and combined knockout backgrounds are a useful tool to identify new mechanisms of immune control during infection. For disease caused by pulmonary Mycobacterium tuberculosis infectio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 933be7f6-f8ba-5e85-84a8-07658a23605d
DOI: 10.1101/2023.02.08.527787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid lethality of mice lacking the phagocyte oxidase and Caspase1/11 following <i>Mycobacterium tuberculosis</i> infectionDOI 10.1101/2023.02.08.527787Read

Immunoevasion and immunosuppression of the macrophage by <i><scp>M</scp>ycobacterium tuberculosis</i>Semantic proximity Read

Mycobacterium tuberculosis prevents inflammasome activation.Semantic proximity Read

BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibilitySemantic proximity Read

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restrictedSemantic proximity Read

Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1Semantic proximity Read

Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection.Semantic proximity Read

<i>Irg1</i> expression in myeloid cells prevents immunopathology during <i>M. tuberculosis</i> infectionSemantic proximity Read

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.Semantic proximity Read

CCR6 is essential for effective immunity against <i>Mycobacterium tuberculosis</i> infection in miceSemantic proximity Read

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis SusceptibilitySemantic proximity Read

Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1Semantic proximity Read

Effective macrophage clearance of <i>Klebsiella pneumoniae</i> requires the inducible nitric oxide synthase iNOS and is independent of reactive oxygen species generated by NADPH oxidaseSemantic proximity Read