Article
Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice.
Disease models & mechanisms - 1 Sept 2015
Niazi Muhammad K K, Dhulekar Nimit, Schmidt Diane, Major Samuel, Cooper Rachel, Abeijon Claudia, Gatti Daniel M, Kramnik Igor, Yener Bulent, Gurcan Metin, Beamer Gillian
Abstract excerpt
Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible humans. Here, we infected Diversity Outbred (DO) mice with ∼100 bacilli by aerosol to model responses in a highly heterogeneous population. Following infection, 'supersusceptible', 'susceptible' and 'resistant' phenotypes emerged. TB disease (reduced survival, weight loss, high bacterial load) correlated strongly with neutrophils,...
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