Article
Cardiac glucose utilization in mice with mutated alpha- and beta-thyroid hormone receptors.
American journal of physiology. Endocrinology and metabolism - 1 Dec 2004
Esaki Takanori, Suzuki Hideyo, Cook Michelle, Shimoji Kazuaki, Cheng Sheue-Yann, Sokoloff Louis, Nunez Jacques
Abstract excerpt
Abnormal thyroid function is usually associated with altered cardiac function. Mutations in the thyroid hormone (TH)-binding region of the TH beta-receptor (TRbeta) that eliminate its TH-binding ability lead to the thyroid hormone resistance syndrome (RTH) in humans, which is characterized by high blood TH levels, goiter, hyperactivity, and tachycardia. Mice with "knock-in" mutations in the TH alpha-receptor...
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