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Article

Differential expression of thyroid hormone receptor isoforms dictates the dominant negative activity of mutant Beta receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2002

Zhang Xiao-Yong, Kaneshige Masahiro, Kamiya Yuji, Kaneshige Kumiko, McPhie Peter, Cheng Sheue-Yann

Abstract excerpt

Mutations in the thyroid hormone receptor beta gene (TRbeta) cause resistance to thyroid hormone (RTH). Genetic analyses indicate that phenotypic manifestation of RTH is due to the dominant negative action of mutant TRbeta. However, the molecular mechanisms underlying the dominant negative action of mutants and how the same mutation results in marked variability of resistance in different tissues in vivo are not...

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PMID: 12198244
DOI: 10.1210/me.2002-0080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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