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Article

Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism.

Endocrinology - 1 Jun 2009

Vujovic Milica, Nordström Kristina, Gauthier Karine, Flamant Frédéric, Visser Theo J, Vennström Björn, Mittag Jens

Abstract excerpt

Mice expressing the mutant thyroid hormone receptor TRalpha1R384C, which has a 10-fold reduced affinity to the ligand T(3), exhibit hypermetabolism due to an overactivation of the sympathetic nervous system. To define the consequences in the liver, we analyzed hepatic metabolism and the regulation of liver genes in the mutant mice. Our results showed that hepatic phosphoenolpyruvate-carboxykinase was up-regulated...

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Source

Identifiers

PMID: 19282388
DOI: 10.1210/en.2008-1085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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