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Article

Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy.

Journal of molecular medicine (Berlin, Germany) - 1 Apr 2009

Luedde Mark, Flögel Ulrich, Knorr Maike, Grundt Christina, Hippe Hans-Joerg, Brors Benedikt, Frank Derk, Haselmann Uta, Antony Claude, Voelkers Mirko, Schrader Juergen, Most Patrick, Lemmer Bjoern, Katus Hugo A, Frey Norbert

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is associated with cardiac hypertrophy, diastolic dysfunction, and sudden death. Recently, it has been suggested that inefficient energy utilization could be a common molecular pathway of HCM-related mutations. We have previously generated transgenic Sprague-Dawley rats overexpressing a truncated cardiac troponin T (DEL-TNT) molecule, displaying typical features of HCM such as...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mitochondria, Heart

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PMID: 19189074
DOI: 10.1007/s00109-008-0436-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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