Article
The Δ337T mutation on the TRβ causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice.
The Journal of endocrinology - 1 Oct 2011
Santiago L A, Santiago D A, Faustino L C, Cordeiro A, Lisboa P C, Wondisford F E, Pazos-Moura C C, Ortiga-Carvalho T M
Abstract excerpt
Mice bearing the genomic mutation Δ337T on the thyroid hormone receptor β (TRβ) gene present the classical signs of resistance to thyroid hormone (TH), with high serum TH and TSH. This mutant TR is unable to bind TH, remains constitutively bound to co-repressors, and has a dominant negative effect on normal TRs. In this study, we show that homozygous (TRβΔ337T) mice for this mutation have reduced body weight,...
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