Resistance to thyroid hormone induced tachycardia in RTHα syndrome.

doi:10.1038/s41467-023-38960-1

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Article

Resistance to thyroid hormone induced tachycardia in RTHα syndrome.

Nature communications - 7 Jun 2023

Dore Riccardo, Watson Laura, Hollidge Stefanie, Krause Christin, Sentis Sarah Christine, Oelkrug Rebecca, Geißler Cathleen, Johann Kornelia, Pedaran Mehdi, Lyons Greta, Lopez-Alcantara Nuria, Resch Julia, Sayk Friedhelm, Iwen Karl Alexander, Franke Andre, Boysen Teide Jens, Dalley Jeffrey W, Lorenz Kristina, Moran Carla, Rennie Kirsten L, Arner Anders, Kirchner Henriette, Chatterjee Krishna, Mittag Jens

Abstract excerpt

Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα patients with thyroxine to overcome tissue hormone resistance does not elevate their heart rate. Cardiac telemetry in male, TRα1 mutant, mice indicates that such persistent bradycardia...

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Identifiers

PMID: 37286550
DOI: 10.1038/s41467-023-38960-1
PMCID: PMC10247713

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