Article
Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.
Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2001
Itoh Y, Esaki T, Kaneshige M, Suzuki H, Cook M, Sokoloff L, Cheng S Y, Nunez J
Abstract excerpt
Brain glucose utilization is markedly depressed in adult rats made cretinous after birth. To ascertain which subtype of thyroid hormone (TH) receptors, TRalpha1 or TRbeta, is involved in the regulation of glucose utilization during brain development, we used the 2-[(14)C]deoxyglucose method in mice with a mutation in either their TRalpha or TRbeta gene. A C insertion produced a frameshift mutation in their...
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