Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor.

Circulation research - 31 Mar 2000

Pazos-Moura C, Abel E D, Boers M E, Moura E, Hampton T G, Wang J, Morgan J P, Wondisford F E

Abstract excerpt

Thyroid hormone deficiency has profound effects on the cardiovascular system, resulting in decreased cardiac contractility, adrenergic responsiveness, and vascular volume and increased peripheral vascular resistance. To determine the importance of direct cardiac effects in the genesis of hypothyroid cardiac dysfunction, the cardiac myocyte was specifically targeted with a mutant thyroid hormone receptor (TR)-beta...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression
Share to Heart
Share to Mice, Transgenic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myocardium

Share to Myosin Heavy Chains

Share to Receptors, Thyroid Hormone

Share to Substrate Specificity

Share to Transgenes

Source

Identifiers

PMID: 10747007
DOI: 10.1161/01.res.86.6.700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor.PMID 10747007Read ↗

Cardiac expression and function of thyroid hormone receptor beta and its PV mutant.Semantic proximity Read ↗

The Impact of a Non-Functional Thyroid Receptor Beta upon Triiodotironine-Induced Cardiac Hypertrophy in Mice.Semantic proximity Read ↗

Altered cardiac phenotype in transgenic mice carrying the delta337 threonine thyroid hormone receptor beta mutant derived from the S family.Semantic proximity Read ↗

Thyroid Hormone-Regulated Cardiac Gene Expression and Cardiovascular DiseaseSemantic proximity Read ↗

Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy.Semantic proximity Read ↗

Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha1.Semantic proximity Read ↗

Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade.Semantic proximity Read ↗

A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor.Semantic proximity Read ↗

Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.Semantic proximity Read ↗

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy.Semantic proximity Read ↗

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.Semantic proximity Read ↗

Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.