Article
Single nucleotide polymorphisms (SNPs) at -238 and -308 positions in the TNFalpha promoter: clinical and bacteriological evaluation in leprosy.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association - 1 Jun 2004
Vanderborght Patrícia R, Matos Haroldo J, Salles Ana M, Vasconcellos Sidra E, Silva-Filho Valcemir F, Huizinga Tom W J, Ottenhoff Tom H M, Sampaio Elisabeth P, Sarno Euzenir N, Santos Adalberto R, Moraes Milton O
Abstract excerpt
Tumor necrosis factor alpha (TNFalpha) plays a key role in orchestrating the complex events involved in inflammation and immune response. The presence of single nucleotide polymorphisms (SNPs) within the promoter region of the TNFa gene has been associated with a number of diseases. The aim of this study was to investigate the distribution of polymorphisms at positions -238 (G/A) and -308 (G/A) at the TNFalpha...
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