Article
TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study.
The Journal of infectious diseases - 15 Oct 2011
Cardoso Cynthia C, Pereira Ana Carla, Brito-de-Souza Vânia N, Duraes Sandra M B, Ribeiro-Alves Marcelo, Nery José Augusto C, Francio Ângela S, Vanderborght Patrícia R, Parelli Francisco P C, Alter Andrea, Salgado Jorge Luís, Sampaio Elizabeth P, Santos Adalberto R, Oliveira Maria Leide W R, Sarno Euzenir N, Schurr Erwin, Mira Marcelo T, Pacheco Antonio G, Moraes Milton O
Abstract excerpt
Leprosy is an infectious disease caused by Mycobacterium leprae. Tumor necrosis factor (TNF) plays a key role in the host response. Some association studies have implicated the single nucleotide polymorphism TNF -308G>A in leprosy susceptibility, but these results are still controversial. We first conducted 4 association studies (2639 individuals) that showed a protective effect of the -308A allele (odds ratio...
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