Article
The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2016
Oliveira Joyce Moura, Rêgo Jamile Leão, de Lima Santana Nadja, Braz Marcos, Jamieson Sarra E, Vieira Thaillamar Silva, Magalhães Thaís Lamêgo, Machado Paulo Roberto Lima, Blackwell Jenefer M, Castellucci Léa C
Abstract excerpt
Leprosy or Hansen's disease is a debilitating chronic granulomatous disease caused by Mycobacterium leprae, with high incidence and prevalence in Brazil. The -308 bp G/A single nucleotide polymorphism (SNP rs1800629) in the tumor necrosis factor (TNF) gene promoter is a proposed risk factor for leprosy. In Brazil, Northern India, Egypt and Nepal, the common G allele was associated with leprosy. In Eastern India,...
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