Article
Role of tumor necrosis factor-alpha and interleukin-10 promoter gene polymorphisms in leprosy.
The Journal of infectious diseases - 1 Dec 2002
Santos Adalberto R, Suffys Philip N, Vanderborght Patrícia R, Moraes Milton O, Vieira Leila M M, Cabello Pedro H, Bakker Aleida M, Matos Haroldo J, Huizinga Tom W J, Ottenhoff Tom H M, Sampaio Elizabeth P, Sarno Euzenir N
Abstract excerpt
Single-nucleotide polymorphisms within the genes coding for tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 have been associated with several infectious diseases. To determine whether such polymorphisms are associated with leprosy, genotyping was performed at the -308 and -238 positions of the promoter of the TNF-alpha gene in 210 and 191 patients with multibacillary (MB) leprosy, respectively; 90 and...
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