Article
Ankylosing spondylitis susceptibility and severity--contribution of TNF gene promoter polymorphisms at positions -238 and -308.
Annals of the New York Academy of Sciences - 1 Sept 2009
Sousa Elsa, Caetano-Lopes Joana, Pinto Patrícia, Pimentel Fernando, Teles José, Canhão Helena, Rodrigues Ana, Resende Catarina, Mourão Ana Filipa, Ribeiro Célia, Pinto Teresa Laura, Rosa Carlos Miranda, da Silva José Alberto Pereira, Branco Jaime, Ventura Francisco, Queiroz Mário Viana, Fonseca João Eurico
Abstract excerpt
Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility...
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