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Article

Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?

Immunobiology - 1 Jan 2006

Aguillón Juan C, Cruzat Andrea, Aravena Octavio, Salazar Lorena, Llanos Carolina, Cuchacovich Miguel

Abstract excerpt

Tumour necrosis factor (TNF), a cytokine mainly produced by macrophages, is associated with a broad spectrum of biological effects, mainly associated with the host defense against microbes. The TNF gene is located on chromosome six within the major histocompatibility complex (MHC). Rheumatoid arthritis (RA) is a systemic autoimmune disease where TNF plays a central role in its etiology and pathogenesis. Written...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 16446172
DOI: 10.1016/j.imbio.2005.09.005

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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