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Article

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.

Nature - 2 Sept 2004

Casali Andreu, Struhl Gary

Abstract excerpt

Morphogens are 'form-generating' substances that spread from localized sites of production and specify distinct cellular outcomes at different concentrations. A cell's perception of morphogen concentration is thought to be determined by the number of active receptors, with inactive receptors making little if any contribution. Patched (Ptc), the receptor for the morphogen Hedgehog (Hh), is active in the absence of...

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Identifiers

PMID: 15300262
DOI: 10.1038/nature02835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.PMID 15300262Read ↗

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