Article
Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1.
Development (Cambridge, England) - 1 Jan 2005
Jeong Juhee, McMahon Andrew P
Abstract excerpt
Upregulation of Patched (Ptc), the Drosophila Hedgehog (Hh) receptor in response to Hh signaling limits the range of signaling within a target field by sequestering Hh. In vertebrates, Ptch1 also exhibits ligand-dependent transcriptional activation, but mutants lacking this response show surprisingly normal early development. The identification of Hh-interacting protein 1 (Hhip1), a vertebrate-specific feedback...
Topics
- Animals
- Bacterial Proteins
- Body Patterning
- COS Cells
- Carrier Proteins
- Gene Expression Regulation
- Intracellular Signaling Peptides and Proteins
- Ligands
- Luminescent Proteins
- Membrane Glycoproteins