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Article

The sonic hedgehog signaling system as a bistable genetic switch.

Biophysical journal - 1 May 2004

Lai Karen, Robertson Matthew J, Schaffer David V

Abstract excerpt

Sonic hedgehog (Shh) controls critical cellular decisions between distinct fates in many systems, particularly in stem cells. The Shh network functions as a genetic switch, and we have theoretically and computationally analyzed how its structure can endow it with the ability to switch fate choices at a threshold Shh concentration. The network is composed of a positive transcriptional feedback loop embedded within...

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Identifiers

PMID: 15111393
DOI: 10.1016/S0006-3495(04)74328-3
PMCID: PMC1304145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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