Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nanoscale organization of hedgehog is essential for long-range signaling.

Cell - 27 Jun 2008

Vyas Neha, Goswami Debanjan, Manonmani A, Sharma Pranav, Ranganath H A, VijayRaghavan K, Shashidhara L S, Sowdhamini R, Mayor Satyajit

Abstract excerpt

Hedgehog (Hh) plays crucial roles in tissue-patterning and activates signaling in Patched (Ptc)-expressing cells. Paracrine signaling requires release and transport over many cell diameters away by a process that requires interaction with heparan sulfate proteoglycans (HSPGs). Here, we examine th...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Cell Membrane
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Green Fluorescent Proteins

Share to Hedgehog Proteins

Share to Heparan Sulfate Proteoglycans

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 18585355
DOI: 10.1016/j.cell.2008.05.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18585355-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nanoscale organization of hedgehog is essential for long-range signaling.PMID 18585355Read ↗

The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexesSemantic proximity Read ↗

Structural basis of sterol recognition by human hedgehog receptor PTCH1Semantic proximity Read ↗

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.Semantic proximity Read ↗

The hedgehog signaling network.Semantic proximity Read ↗

In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter.Semantic proximity Read ↗

Genetic and biochemical definition of the Hedgehog receptor.Semantic proximity Read ↗

Design principles of a membrane-spanning ubiquitin ligase.Semantic proximity Read ↗

The full-length unprocessed hedgehog protein is an active signaling molecule.Semantic proximity Read ↗

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.Semantic proximity Read ↗

Hedgehog regulates smoothened activity by inducing a conformational switch.Semantic proximity Read ↗

Autoproteolysis in hedgehog protein biogenesis.Semantic proximity Read ↗

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.