Article
Nanoscale organization of hedgehog is essential for long-range signaling.
Cell - 27 Jun 2008
Vyas Neha, Goswami Debanjan, Manonmani A, Sharma Pranav, Ranganath H A, VijayRaghavan K, Shashidhara L S, Sowdhamini R, Mayor Satyajit
Abstract excerpt
Hedgehog (Hh) plays crucial roles in tissue-patterning and activates signaling in Patched (Ptc)-expressing cells. Paracrine signaling requires release and transport over many cell diameters away by a process that requires interaction with heparan sulfate proteoglycans (HSPGs). Here, we examine the organization of functional, fluorescently tagged variants in living cells by using optical imaging, FRET microscopy,...
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