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Article

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.

Cell - 18 Aug 2000

Denef N, Neubüser D, Perez L, Cohen S M

Abstract excerpt

Secreted signaling proteins of the Hedgehog family organize spatial pattern during animal development. Two integral membrane proteins have been identified with distinct roles in Hedgehog signaling. Patched functions in Hedgehog binding, and Smoothened functions in transducing the signal. Current models view Patched and Smoothened as a preformed receptor complex that is activated by Hedgehog binding. Here we...

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Source

Identifiers

PMID: 10966113
DOI: 10.1016/s0092-8674(00)00056-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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