Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual roles for patched in sequestering and transducing Hedgehog.

Cell - 1 Nov 1996

Chen Y, Struhl G

Abstract excerpt

Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Drosophila melanogaster
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Membrane Proteins

Share to Multigene Family

Share to Proteins

Share to Signal Transduction

Source

Identifiers

PMID: 8898207
DOI: 10.1016/s0092-8674(00)81374-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual roles for patched in sequestering and transducing Hedgehog.PMID 8898207Read ↗

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.Semantic proximity Read ↗

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking.Semantic proximity Read ↗

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.Semantic proximity Read ↗

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.Semantic proximity Read ↗

Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 SecretionSemantic proximity Read ↗

Characterization of two patched receptors for the vertebrate hedgehog protein familySemantic proximity Read ↗

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.Semantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

The role of ciliary trafficking in Hedgehog receptor signalingSemantic proximity Read ↗

Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.Semantic proximity Read ↗

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.Semantic proximity Read ↗

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.