Article
A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.
Development (Cambridge, England) - 1 Apr 2002
Shyamala Baragur V, Bhat Krishna Moorthi
Abstract excerpt
The transmembrane receptor Patched regulates several developmental processes in both invertebrates and vertebrates. In vertebrates, Patched also acts as a tumor suppressor. The Patched pathway normally operates by negatively regulating Smoothened, a G-protein-coupled receptor; binding of Hedgehog ligand to Patched relieves this negative interaction and allows signaling by Smoothened. We show that Ptc regulates...
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