Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2021

Petrov Kostadin, de Almeida Magalhaes Taciani, Salic Adrian

Abstract excerpt

Hedgehog signaling is fundamental in animal embryogenesis, and its dysregulation causes cancer and birth defects. The pathway is triggered when the Hedgehog ligand inhibits the Patched1 membrane receptor, relieving repression that Patched1 exerts on the GPCR-like protein Smoothened. While it is clear how loss-of-function Patched1 mutations cause hyperactive Hedgehog signaling and cancer, how other Patched1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Holoprosencephaly

Share to Patched-1 Receptor

Share to Protein Domains

Share to Smoothened Receptor

Source

Open in PubMed Open full text

Identifiers

PMID: 33526656
DOI: 10.1073/pnas.2006800118
PMCID: PMC8017988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.PMID 33526656Read ↗

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.Semantic proximity Read ↗

The role of ciliary trafficking in Hedgehog receptor signalingSemantic proximity Read ↗

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.Semantic proximity Read ↗

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened.Semantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

The patched signaling pathway in tumorigenesis and development: lessons from animal models.Semantic proximity Read ↗

A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development.Semantic proximity Read ↗

Patched1 is required in neural crest cells for the prevention of orofacial clefts.Semantic proximity Read ↗

Dispatched uses Na+ flux to power release of lipid-modified Hedgehog.Semantic proximity Read ↗

Bi-allelic Variations of SMO in Humans Cause a Broad Spectrum of Developmental Anomalies Due to Abnormal Hedgehog Signaling.Semantic proximity Read ↗

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Semantic proximity Read ↗

A ubiquitin-based mechanism for the oligogenic inheritance of heterotaxy and heart defectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.